Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sex Differences in Behavior and Molecular Pathology in the 5XFAD Model.

Journal of Alzheimer's disease : JAD - 1 Jan 2022

Sil Annesha, Erfani Arina, Lamb Nicola, Copland Rachel, Riedel Gernot, Platt Bettina

Abstract excerpt

BACKGROUND: The prevalence of Alzheimer's disease (AD) is greater in women compared to men, but the reasons for this remain unknown. This sex difference has been widely neglected in experimental studies using transgenic mouse models of AD. OBJECTIVE: Here, we studied behavior and molecular pathology of 5-month-old 5XFAD mice, which express mutated human amyloid precursor protein and presenilin-1 on a C57BL/6J...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Mice, Inbred C57BL

Share to Mice, Transgenic

Share to Pathology, Molecular

Share to Presenilin-1

Share to Sex Characteristics

Source

Identifiers

PMID: 34864660
DOI: 10.3233/JAD-210523

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sex Differences in Behavior and Molecular Pathology in the 5XFAD Model.PMID 34864660Read ↗

Sex differences in behaviour and molecular pathology in the 5XFAD modelSemantic proximity Read ↗

Chronic social isolation-unpredictable stress induces early-onset cognitive deficits and exacerbates Aβ accumulation in the 5xFAD mouse model of Alzheimer's disease.Semantic proximity Read ↗

Sex Differences between Neuronal Loss and the Early Onset of Amyloid Deposits and Behavioral Consequences in 5xFAD Transgenic Mouse as a Model for Alzheimer’s DiseaseSemantic proximity Read ↗

Sex- and brain region-specific acceleration of β-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's diseaseSemantic proximity Read ↗

Females outperform males in spatial learning despite increased amyloid plaques and microgliosis in a TgF344-AD rat model of Alzheimer’s diseaseSemantic proximity Read ↗

Sex-related dimorphism in dentate gyrus atrophy and behavioral phenotypes in an inducible tTa:APPsi transgenic model of Alzheimer's disease.Semantic proximity Read ↗

APOE genotype and sex modulate Alzheimer’s disease pathology in aged EFAD transgenic miceSemantic proximity Read ↗

Social Interaction Deficits Emerge Alongside Anxiety-Like Behavior in TgF344-AD RatsSemantic proximity Read ↗

Sexual Dimorphism in the 3xTg-AD Mouse Model and Its Impact on Pre-Clinical ResearchSemantic proximity Read ↗

Sex‐biased hippocampal pathology in the 5XFAD mouse model of Alzheimer's disease: A multi‐omic analysisSemantic proximity Read ↗

Sexual dimorphism in behavior, neuropathology, and biomarkers in a tau P301S mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

Epigenetic mechanisms underlying cognitive impairment and Alzheimer disease hallmarks in 5XFAD miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.