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In vitro and in vivo correlates of physiological and neoplastic human Fallopian tube stem cells

28 Sept 2015

Abstract excerpt

High-grade serous cancer (HGSC) progresses to advanced stages without symptoms and the 5-year survival rate is a dismal 30%. Recent studies of ovaries and Fallopian tubes in patients with BRCA1 or BRCA2 mutations have documented a pre-metastatic intramucosal neoplasm that is found almost exclusively in the Fallopian tube, termed 'serous tubal intraepithelial carcinoma' or STIC. Moreover, other proliferations,...

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PMID: 26415052
DOI: 10.1002/path.4649

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