Mutations within the selectivity filter reveal that Kv1 channels have distinct propensities to slow inactivate.

Abstract excerpt

Voltage-activated potassium (Kv) channels open in response to membrane depolarization and subsequently inactivate through distinct mechanisms. For the model Shaker Kv channel from Drosophila, fast N-type inactivation is thought to occur by a mechanism involving blockade of the internal pore by the N-terminus, whereas slow C-type inactivation results from conformational changes in the ion selectivity filter in the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Ion Channel Gating
• Share to Mutation
• Share to Potassium