Article
Role of outer-pore residue Y380 in U-type inactivation of KV2.1 channels.
The Journal of membrane biology - 1 Aug 2013
Jamieson Quentin, Jones Stephen W
Abstract excerpt
The interpretation of slow inactivation in potassium channels has been strongly influenced by work on C-type inactivation in Shaker channels. Slow inactivation in Shaker and some other potassium channels can be dramatically modulated by the state of the pore, including mutations at outer pore residue T449, which altered inactivation kinetics up to 100-fold. KV2.1, another voltage-dependent potassium channel,...
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