Article
How does the W434F mutation block current in Shaker potassium channels?
The Journal of general physiology - 1 Jun 1997
Yang Y, Yan Y, Sigworth F J
Abstract excerpt
The mutation W434F produces an apparently complete block of potassium current in Shaker channels expressed in Xenopus oocytes. Tandem tetrameric constructs containing one or two subunits with this mutation showed rapid inactivation, although the NH2-terminal inactivation domain was absent from these constructs. The inactivation showed a selective dependence on external cations and was slowed by external TEA;...
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