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Article

Mechanism of accelerated current decay caused by an episodic ataxia type-1-associated mutant in a potassium channel pore.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 30 Nov 2011

Peters Christian J, Werry Daniel, Gill Hira S, Accili Eric A, Fedida David

Abstract excerpt

In Kv1.1, single point mutants found below the channel activation gate at residue V408 are associated with human episodic ataxia type-1, and impair channel function by accelerating decay of outward current during periods of membrane depolarization and channel opening. This decay is usually attributed to C-type inactivation, but here we provide evidence that this is not the case. Using voltage-clamp fluorimetry in...

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Identifiers

PMID: 22131406
DOI: 10.1523/JNEUROSCI.2940-11.2011
PMCID: PMC6623802

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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