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Article

Dynamic regulation of myofibroblast phenotype in cellular senescence.

Aging cell - 1 Apr 2022

López-Antona Irene, Contreras-Jurado Constanza, Luque-Martín Laura, Carpintero-Leyva Antonio, González-Méndez Paula, Palmero Ignacio

Abstract excerpt

Cellular senescence is an antiproliferative response with a critical role in the control of cellular balance in diverse physiological and pathological settings. Here, we set to study the impact of senescence on the regulation of cell plasticity, focusing on the regulation of the myofibroblastic phenotype in primary fibroblasts. Myofibroblasts are contractile, highly fibrogenic cells with key roles in wound...

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Identifiers

PMID: 35266275
DOI: 10.1111/acel.13580
PMCID: PMC9009235

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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