Article
Identification of Senescent Cells in the Bone Microenvironment.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 2016
Farr Joshua N, Fraser Daniel G, Wang Haitao, Jaehn Katharina, Ogrodnik Mikolaj B, Weivoda Megan M, Drake Matthew T, Tchkonia Tamara, LeBrasseur Nathan K, Kirkland James L, Bonewald Lynda F, Pignolo Robert J, Monroe David G, Khosla Sundeep
Abstract excerpt
Cellular senescence is a fundamental mechanism by which cells remain metabolically active yet cease dividing and undergo distinct phenotypic alterations, including upregulation of p16Ink4a , profound secretome changes, telomere shortening, and decondensation of pericentromeric satellite DNA. Because senescent cells accumulate in multiple tissues with aging, these cells and the dysfunctional factors they secrete,...
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