In Vivo 2-Hydroxyglutarate Monitoring With Edited MR Spectroscopy for the Follow-up of IDH-Mutant Diffuse Gliomas: The IDASPE Prospective Study.

doi:10.1212/WNL.0000000000201137

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In Vivo 2-Hydroxyglutarate Monitoring With Edited MR Spectroscopy for the Follow-up of IDH-Mutant Diffuse Gliomas: The IDASPE Prospective Study.

Neurology - 3 Jan 2023

Di Stefano Anna Luisa, Nichelli Lucia, Berzero Giulia, Valabregue Romain, Touat Mehdi, Capelle Laurent, Pontoizeau Clément, Bielle Franck, Lerond Julie, Giry Marine, Villa Chiara, Baussart Bertrand, Dehais Caroline, Galanaud Damien, Baldini Capucine, Savatovsky Julien, Dhermain Frédéric, Deelchand Dinesh K, Ottolenghi Chris, Lehéricy Stéphane, Marjańska Małgorzata, Branzoli Francesca, Sanson Marc

Abstract excerpt

BACKGROUND AND OBJECTIVES: D-2-hydroxyglutarate (2HG) characterizes IDH-mutant gliomas and can be detected and quantified with edited MRS (MEGA-PRESS). In this study, we investigated the clinical, radiologic, and molecular parameters affecting 2HG levels. METHODS: MEGA-PRESS data were acquired in 71 patients with glioma (24 untreated, 47 treated) on a 3 T system. Eighteen patients were followed during cytotoxic...

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PMID: 36180241
DOI: 10.1212/WNL.0000000000201137
PMCID: PMC9827125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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