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Article

Magnetic resonance of 2-hydroxyglutarate in IDH1-mutated low-grade gliomas.

Science translational medicine - 11 Jan 2012

Elkhaled Adam, Jalbert Llewellyn E, Phillips Joanna J, Yoshihara Hikari A I, Parvataneni Rupa, Srinivasan Radhika, Bourne Gabriela, Berger Mitchel S, Chang Susan M, Cha Soonmee, Nelson Sarah J

Abstract excerpt

Recent studies have indicated that a significant survival advantage is conferred to patients with gliomas whose lesions harbor mutations in the genes isocitrate dehydrogenase 1 and 2 (IDH1/2). IDH1/2 mutations result in aberrant enzymatic production of the potential oncometabolite D-2-hydroxyglutarate (2HG). Here, we report on the ex vivo detection of 2HG in IDH1-mutated tissue samples from patients with...

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Identifiers

PMID: 22238333
DOI: 10.1126/scitranslmed.3002796
PMCID: PMC3772177

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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