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Article

Spectroscopic imaging of D-2-hydroxyglutarate and other metabolites in pre-surgical patients with IDH-mutant lower-grade gliomas.

Journal of neuro-oncology - 1 Aug 2022

Autry Adam W, Lafontaine Marisa, Jalbert Llewellyn, Phillips Elizabeth, Phillips Joanna J, Villanueva-Meyer Javier, Berger Mitchel S, Chang Susan M, Li Yan

Abstract excerpt

PURPOSE: Prognostically favorable IDH-mutant gliomas are known to produce oncometabolite D-2-hydroxyglutarate (2HG). In this study, we investigated metabolite-based features of patients with grade 2 and 3 glioma using 2HG-specific in vivo MR spectroscopy, to determine their relationship with image-guided tissue pathology and predictive role in progression-free survival (PFS). METHODS: Forty-five patients received...

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Identifiers

PMID: 35672531
DOI: 10.1007/s11060-022-04042-3
PMCID: PMC9325821

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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