Ivosidenib and Vorasidenib Decrease Intratumoral 2-Hydroxyglutarate and Total Choline Levels in Patients with Lower-Grade Glioma: An In Vivo MR Spectroscopy Study.

doi:10.1158/1078-0432.CCR-25-4313

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Article

Ivosidenib and Vorasidenib Decrease Intratumoral 2-Hydroxyglutarate and Total Choline Levels in Patients with Lower-Grade Glioma: An In Vivo MR Spectroscopy Study.

Clinical cancer research : an official journal of the American Association for Cancer Research - 3 Aug 2026

Simicic Dunja, Alcicek Seyma, Blair Lindsay, Saint-Germain Max, Zöllner Helge J, Ritter Zsombor, Blakeley Jaishri O, Davies-Jenkins Christopher W, Holdhoff Matthias, Laterra John, Bettegowda Chetan, Schreck Karisa C, Lin Doris D, Barker Peter B, Kamson David O, Oeltzschner Georg

Abstract excerpt

PURPOSE: Isocitrate dehydrogenase (IDH)-mutant (mIDH) gliomas are slow-growing infiltrating tumors of astrocytic or oligodendroglial origin. Mutated metabolic enzymes IDH1 or IDH2 lead to the production of 2-hydroxyglutarate (2HG) that can be measured with optimized in vivo magnetic resonance spectroscopy (MRS). As the 2HG oncometabolite plays a key role in the molecular pathogenesis of mIDH tumor, direct...

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PMID: 41995710
DOI: 10.1158/1078-0432.CCR-25-4313
PMCID: PMC13430226

Genes

IDH1
IDH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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