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Article

Detection of 2-hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy.

Science translational medicine - 11 Jan 2012

Andronesi Ovidiu C, Kim Grace S, Gerstner Elizabeth, Batchelor Tracy, Tzika Aria A, Fantin Valeria R, Vander Heiden Matthew G, Sorensen A Gregory

Abstract excerpt

Mutations in the gene isocitrate dehydrogenase 1 (IDH1) are present in up to 86% of grade II and III gliomas and secondary glioblastoma. Arginine 132 (R132) mutations in the enzyme IDH1 result in excess production of the metabolite 2-hydroxyglutarate (2HG), which could be used as a biomarker for this subset of gliomas. Here, we use optimized in vivo spectral-editing and two-dimensional (2D) correlation magnetic...

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Source

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Identifiers

PMID: 22238332
DOI: 10.1126/scitranslmed.3002693
PMCID: PMC3720836

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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