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Article

Imaging biomarkers for detecting IDH mutations and monitoring response to novel targeted therapies: Current insights and future perspectives.

Neuro-oncology - 1 May 2026

Rajan Archith, Castro Felipe Rosero, de Godoy Laiz Laura, Hanaoka Mauro, Turk Sevcan, Desiderio Lisa, Stupp Roger, Mohan Suyash, Chawla Sanjeev

Abstract excerpt

Isocitrate dehydrogenase (IDH) mutant gliomas represent a unique molecular subset of gliomas with distinct metabolic and microstructural characteristics. The recent approval of targeted IDH inhibitors marks a significant advancement in glioma therapy, thereby necessitating robust, quantitative methods for noninvasive assessment of treatment response. This review provides an overview of advanced multiparametric...

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Identifiers

PMID: 41698848
DOI: 10.1093/neuonc/noag028
PMCID: PMC13186471

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