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Article

Diagnostic accuracy of 1H-MRS in detecting the oncometabolite 2-hydroxyglutarate (2HG) in adult-type diffuse gliomas.

Journal of neuro-oncology - 14 May 2026

Hebda Anna, Wawrzyniak Paweł, Heinze Sylwia, Mazgaj Patrycja, Sadowski Daniel, Oczko-Wojciechowska Małgorzata, Nowicka Elżbieta, Chmielik Ewa, Bobek-Billewicz Barbara

Abstract excerpt

PURPOSE: To evaluate the diagnostic accuracy of three proton magnetic resonance spectroscopy (1H-MRS) strategies-short echo (TE 30 ms), intermediate echo (TE 97 ms), and MEGA-PRESS-for detecting the oncometabolite 2-hydroxyglutarate (2HG) to non-invasively determine isocitrate dehydrogenase (IDH) mutation status in adult-type diffuse gliomas. METHODS: A cohort of 152 patients with adult-type diffuse gliomas (84...

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Identifiers

PMID: 42133138
DOI: 10.1007/s11060-026-05600-9
PMCID: PMC13176003

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