Article

Heatrich-BS enables efficient CpG enrichment and highly scalable cell-free DNA methylation profiling

2021-04-06

Abstract excerpt

Genome wide analysis of cell-free DNA (cfDNA) methylation profile has been shown to be a promising approach for sensitive and specific multi-cancer detection. However, scaling these assays for clinical translation is impractical due to the high cost of whole genome bisulfite sequencing. We showed that the small fraction of GC-rich genome is highly enriched in CpG sites and disproportionately harbored the majority...

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Literature Corpus work: 3882d610-b881-5f99-9d43-9c6f6417a662
DOI: 10.1101/2021.04.05.437976

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