Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evaluating the impact of glucokinase activation on risk of cardiovascular disease: a Mendelian randomisation analysis

23 Sept 2022

Abstract excerpt

Abstract Background Glucokinase activators (GKAs) are an emerging class of glucose lowering drugs that activate the glucose-sensing enzyme glucokinase (GK). Pending formal cardiovascular outcome trials, we applied two-sample Mendelian randomisation (MR) to investigate the impact of GK activation on risk of cardiovascular diseases. Methods We used independent genetic variants in or around the glucokinase gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Associations and Epidemiology
Share to Glycosylation and Glycoproteins Research
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36151532
DOI: 10.1186/s12933-022-01613-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evaluating the impact of glucokinase activation on risk of cardiovascular disease: a Mendelian randomisation analysisPMID 36151532Read ↗

Genetic evidence for the effects of glucokinase activation on frailty-related outcomes: A Mendelian randomisation study.Semantic proximity Read ↗

Impaired GK-GKRP interaction rather than direct GK activation worsens lipid profiles and contributes to long-term complications: a Mendelian randomization study.Semantic proximity Read ↗

Using genetics to assess the association of commonly used antihypertensive drugs with diabetes, glycaemic traits and lipids: a trans-ancestry Mendelian randomisation studySemantic proximity Read ↗

Glucokinase activator, circulating metabolites, and cardio-cerebrovascular diseases: a Mendelian randomization study.Semantic proximity Read ↗

Lipids, Blood Pressure, and Diabetes Mellitus on Risk of Cardiovascular Diseases in East Asians: A Mendelian Randomization StudySemantic proximity Read ↗

Genetically Driven Hyperglycemia Increases Risk of Coronary Artery Disease Separately From Type 2 Diabetes.Semantic proximity Read ↗

Differentiating Associations of Glycemic Traits With Atherosclerotic and Thrombotic Outcomes: Mendelian Randomization Investigation.Semantic proximity Read ↗

Nonfasting glucose, ischemic heart disease, and myocardial infarction: a Mendelian randomization study.Semantic proximity Read ↗

Primary Aldosteronism and Risk of Cardiovascular Outcomes: Genome-Wide Association and Mendelian Randomization Study.Semantic proximity Read ↗

ASGR1 inhibitors, inflammation, and heart failure: A Mendelian randomization analysis.Semantic proximity Read ↗

ACE and Type 2 Diabetes Risk: A Mendelian Randomization Study.Semantic proximity Read ↗

Dose-response relationship between genetically proxied average blood glucose levels and incident coronary heart disease in individuals without diabetes mellitus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.