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Article

Genetic evidence for the effects of glucokinase activation on frailty-related outcomes: A Mendelian randomisation study.

Diabetes, obesity & metabolism - 1 Jun 2025

Hua Rong, Shi Mai, Chow Elaine, Yang Aimin, Cheung Yin Ting

Abstract excerpt

AIMS: We aimed to use the Mendelian randomisation (MR) design to investigate the potential causal effects of glucokinase (GK) activation on frailty-related outcomes and to explore the potential mediating effects of metabolic and inflammatory biomarkers. MATERIALS AND METHODS: Seventeen independent single-nucleotide polymorphisms (SNPs) located within the GCK gene and significantly correlated with the glycated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40035195
DOI: 10.1111/dom.16312
PMCID: PMC12046474

Genes

GK
GCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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