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Article

ASGR1 inhibitors, inflammation, and heart failure: A Mendelian randomization analysis.

Lipids - 1 Nov 2025

Ye Xingsheng, Yang Miaomiao, Hong Yinghao, Lin Zhizhan, Peng Jian, He Liwei

Abstract excerpt

This study investigates the causal relationship between Asialoglycoprotein receptor 1 (ASGR1) inhibitors, inflammation, and heart failure (HF). Leveraging data from the Global Lipids Genetics Consortium (2021) and the UK Biobank, we identified instrumental variables for ASGR1 and validated these genetic instruments using coronary heart disease (CHD) patients as positive controls. We employed Instrumental variable...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 40391737
DOI: 10.1002/lipd.12446

Genes

ASGR1
LDLR
LIF
PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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