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Article

Glucokinase activator, circulating metabolites, and cardio-cerebrovascular diseases: a Mendelian randomization study.

Cardiovascular diabetology - 30 Jul 2025

Wang Xiaohan, Cheng Weimeng, Xu Tingting, He Ping, Li Tianyue, Zhang Ying, Wei Zhonghai

Abstract excerpt

BACKGROUND: Glucokinase activator (GKA) has shown potential in influencing cardio-cerebrovascular diseases (CVDs), yet its metabolic mechanism remains unclear. Circulating metabolites play a significant role in the etiology of CVDs. We hypothesized that the effects of GKA on cardio-cerebrovascular outcomes are mediated through circulating metabolites. METHODS: We selected genetic variants associated with GCK mRNA...

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Identifiers

PMID: 40739561
DOI: 10.1186/s12933-025-02851-0
PMCID: PMC12312601

Genes

CAD
GCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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