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Genetically Driven Hyperglycemia Increases Risk of Coronary Artery Disease Separately From Type 2 Diabetes.

Diabetes care - 1 May 2017

Merino Jordi, Leong Aaron, Posner Daniel C, Porneala Bianca, Masana Lluís, Dupuis Josée, Florez Jose C

Abstract excerpt

OBJECTIVE: This study tested the hypothesis that genetically raised hyperglycemia increases coronary artery disease (CAD) risk separately from the risk conferred by type 2 diabetes as a whole. RESEARCH DESIGN AND METHODS: We conducted a Mendelian randomization (MR) analysis using summary-level statistics from the largest published meta-analyses of genome-wide association studies (GWAS) for fasting glucose (FG) (n...

Topics

Blood Glucose
Coronary Artery Disease
Diabetes Mellitus, Type 2
Fasting
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Hyperglycemia
Mendelian Randomization Analysis
Odds Ratio

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28298470
DOI: 10.2337/dc16-2625
PMCID: PMC5399655

Genes

CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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