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Article

Primary Aldosteronism and Risk of Cardiovascular Outcomes: Genome-Wide Association and Mendelian Randomization Study.

Journal of the American Heart Association - 6 Aug 2024

Inoue Kosuke, Naito Tatsuhiko, Fuji Ryosuke, Sonehara Kyuto, Yamamoto Kenichi, Baba Ryuta, Kodama Takaya, Otagaki Yu, Okada Akira, Itcho Kiyotaka, Kobuke Kazuhiro, Ohno Haruya, Morisaki Takayuki, Hattori Noboru, Goto Atsushi, Nishikawa Tetsuo, Oki Kenji, Okada Yukinori

Abstract excerpt

BACKGROUND: Observational studies have reported associations between primary aldosteronism (PA) and cardiovascular outcomes, including coronary artery diseases (CAD), congestive heart failure (CHF), and stroke. However, establishing causality remains a challenge due to the lack of randomized controlled trial data on this topic. We thus aimed to investigate the causal relationship between PA and the risk of...

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Identifiers

PMID: 39101507
DOI: 10.1161/JAHA.123.034180

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