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Differentiating Associations of Glycemic Traits With Atherosclerotic and Thrombotic Outcomes: Mendelian Randomization Investigation.

Diabetes - 1 Oct 2022

Yuan Shuai, Mason Amy M, Burgess Stephen, Larsson Susanna C

Abstract excerpt

We conducted a Mendelian randomization analysis to differentiate associations of four glycemic indicators with a broad range of atherosclerotic and thrombotic diseases. Independent genetic variants associated with fasting glucose (FG), 2 h glucose after an oral glucose challenge (2hGlu), fasting insulin (FI), and glycated hemoglobin (HbA1c) at the genome-wide significance threshold were used as instrumental...

Topics

Atherosclerosis
Blood Glucose
Genome-Wide Association Study
Glycated Hemoglobin
Humans
Insulin
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide
Stroke

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Identifiers

PMID: 35499407
DOI: 10.2337/db21-0905
PMCID: PMC7613853

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