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Article

ACE and Type 2 Diabetes Risk: A Mendelian Randomization Study.

Diabetes care - 1 Apr 2020

Pigeyre Marie, Sjaarda Jennifer, Chong Michael, Hess Sibylle, Bosch Jackie, Yusuf Salim, Gerstein Hertzel, Paré Guillaume

Abstract excerpt

OBJECTIVE: To determine whether ACE inhibitors reduce the risk of type 2 diabetes using a Mendelian randomization (MR) approach. RESEARCH DESIGN AND METHODS: A two-sample MR analysis included 17 independent genetic variants associated with ACE serum concentration in 4,147 participants from the Outcome Reduction with Initial Glargine INtervention (ORIGIN) (clinical trial reg. no. NCT00069784) trial, and their...

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Identifiers

PMID: 32019855
DOI: 10.2337/dc19-1973

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