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TERRA G-quadruplex RNA interaction with TRF2 GAR domain is required for telomere integrity

10 Feb 2021

Abstract excerpt

Telomere dysfunction causes chromosomal instability which is associated with many cancers and age-related diseases. The non-coding telomeric repeat-containing RNA (TERRA) forms a structural and regulatory component of the telomere that is implicated in telomere maintenance and chromosomal end protection. The basic N-terminal Gly/Arg-rich (GAR) domain of telomeric repeat-binding factor 2 (TRF2) can bind TERRA but...

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Share to Advanced biosensing and bioanalysis techniques
Share to RNA Interference and Gene Delivery
Share to Telomeres, Telomerase, and Senescence

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PMID: 33568696
DOI: 10.1038/s41598-021-82406-x

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TERRA G-quadruplex RNA interaction with TRF2 GAR domain is required for telomere integrityPMID 33568696Read ↗

In Vitro Characterization of the Physical Interactions between the Long Noncoding RNA TERRA and the Telomeric Proteins TRF1 and TRF2Semantic proximity Read ↗

Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integritySemantic proximity Read ↗

Functional characterization of the TERRA transcriptome at damaged telomeresSemantic proximity Read ↗

Role of TERRA in the Regulation of Telomere LengthSemantic proximity Read ↗

The Emerging Roles of TERRA in Telomere Maintenance and Genome StabilitySemantic proximity Read ↗

BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage.Semantic proximity Read ↗

Telomeric Noncoding RNA TERRA Is Induced by Telomere Shortening to Nucleate Telomerase Molecules at Short TelomeresSemantic proximity Read ↗

R-Loops at Chromosome Ends: From Formation, Regulation, and Cellular ConsequenceSemantic proximity Read ↗

TERRA RNA Binding to TRF2 Facilitates Heterochromatin Formation and ORC Recruitment at TelomeresSemantic proximity Read ↗

The crosstalk of telomere dysfunction and inflammation through cell-free TERRA containing exosomesSemantic proximity Read ↗

The RNA-binding motif protein 14 regulates telomere integrity at the interface of TERRA and telomeric R-loopsSemantic proximity Read ↗

TERRA RNA Antagonizes ATRX and Protects TelomeresSemantic proximity Read ↗

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