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Article

Functional characterization of the TERRA transcriptome at damaged telomeres

31 Oct 2014

Abstract excerpt

Telomere deprotection occurs during tumorigenesis and aging upon telomere shortening or loss of the telomeric shelterin component TRF2. Deprotected telomeres undergo changes in chromatin structure and elicit a DNA damage response (DDR) that leads to cellular senescence. The telomeric long noncoding RNA TERRA has been implicated in modulating the structure and processing of deprotected telomeres. Here, we...

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Share to Advanced biosensing and bioanalysis techniques
Share to RNA regulation and disease
Share to Telomeres, Telomerase, and Senescence

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PMID: 25359189
DOI: 10.1038/ncomms6379

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TERRA recruitment of polycomb to telomeres is essential for histone trymethylation marks at telomeric heterochromatinSemantic proximity Read ↗

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