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The N-terminal domains of TRF1 and TRF2 regulate their ability to condense telomeric DNA

1 Dec 2011

Abstract excerpt

TRF1 and TRF2 are key proteins in human telomeres, which, despite their similarities, have different behaviors upon DNA binding. Previous work has shown that unlike TRF1, TRF2 condenses telomeric, thus creating consequential negative torsion on the adjacent DNA, a property that is thought to lead to the stimulation of single-strand invasion and was proposed to favor telomeric DNA looping. In this report, we show...

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PMID: 22139926
DOI: 10.1093/nar/gkr1116

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