The telomere maintenance mechanism spectrum and its dynamics in gliomas.

doi:10.1186/s13073-022-01095-x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The telomere maintenance mechanism spectrum and its dynamics in gliomas.

Genome medicine - 11 Aug 2022

Kim Sojin, Chowdhury Tamrin, Yu Hyeon Jong, Kahng Jee Ye, Lee Chae Eun, Choi Seung Ah, Kim Kyung-Min, Kang Ho, Lee Joo Ho, Lee Soon-Tae, Won Jae-Kyung, Kim Kyung Hyun, Kim Min-Sung, Lee Ji Yeoun, Kim Jin Wook, Kim Yong-Hwy, Kim Tae Min, Choi Seung Hong, Phi Ji Hoon, Shin Young-Kyoung, Ku Ja-Lok, Lee Sungyoung, Yun Hongseok, Lee Hwajin, Kim Dokyoung, Kim Kyoungmi, Hur Junho K, Park Sung-Hye, Kim Seung-Ki, Park Chul-Kee

Abstract excerpt

BACKGROUND: The activation of the telomere maintenance mechanism (TMM) is one of the critical drivers of cancer cell immortality. In gliomas, TERT expression and TERT promoter mutation are considered to reliably indicate telomerase activation, while ATRX mutation and/or loss indicates an alternative lengthening of telomeres (ALT). However, these relationships have not been extensively validated in tumor tissues....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Corneal surgery and disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glioma

Share to Mutation

Share to Nuclear Structure and Function

Share to Telomerase

Share to Telomere

Share to Telomere Homeostasis

Share to Telomeres, Telomerase, and Senescence

Source

Open in PubMed Open full text

Identifiers

PMID: 35953846
DOI: 10.1186/s13073-022-01095-x
PMCID: PMC9367055

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The telomere maintenance mechanism spectrum and its dynamics in gliomas.PMID 35953846Read ↗

Mechanisms of telomere maintenance and associated therapeutic vulnerabilities in malignant gliomasSemantic proximity Read ↗

Telomere sequence content can be used to determine ALT activity in tumours.Semantic proximity Read ↗

Telomere maintenance and the etiology of adult gliomaSemantic proximity Read ↗

Telomere Maintenance Mechanisms in CancerSemantic proximity Read ↗

When the Ends Are Really the Beginnings: Targeting Telomerase for Treatment of GBM.Semantic proximity Read ↗

Epigenetic Regulation of Telomere Maintenance for Therapeutic Interventions in GliomasSemantic proximity Read ↗

The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma.Semantic proximity Read ↗

Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancerSemantic proximity Read ↗

Functional analysis of telomere maintenance mechanisms is more informative than immunohistochemistry for ATRX mutation interpretation in Gliomas.Semantic proximity Read ↗

ALT in Pediatric High-Grade Gliomas Can Occur without <i>ATRX</i> Mutation and is Enriched in Patients with Pathogenic Germline MMR VariantsSemantic proximity Read ↗

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.Semantic proximity Read ↗

Alternative lengthening of telomeres (ALT) in pediatric high-grade gliomas can occur without ATRX mutation and is enriched in patients with pathogenic germline mismatch repair (MMR) variants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.