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The Spike-Stabilizing D614G Mutation Interacts with S1/S2 Cleavage Site Mutations To Promote the Infectious Potential of SARS-CoV-2 Variants.

Journal of virology - 12 Oct 2022

Gellenoncourt Stacy, Saunders Nell, Robinot Rémy, Auguste Lucas, Rajah Maaran Michael, Kervevan Jérôme, Jeger-Madiot Raphaël, Staropoli Isabelle, Planchais Cyril, Mouquet Hugo, Buchrieser Julian, Schwartz Olivier, Chakrabarti Lisa A

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remained genetically stable during the first 3 months of the pandemic, before acquiring a D614G spike mutation that rapidly spread worldwide and then generating successive waves of viral variants with increasingly high transmissibility. We set out to evaluate possible epistatic interactions between the early-occurring D614G mutation and the more...

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Identifiers

PMID: 36121299
DOI: 10.1128/jvi.01301-22
PMCID: PMC9555207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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