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Article

SARS-CoV-2 omicron variants harbor spike protein mutations responsible for their attenuated fusogenic phenotype.

Communications biology - 24 May 2023

Park Seung Bum, Khan Mohsin, Chiliveri Sai Chaitanya, Hu Xin, Irvin Parker, Leek Madeleine, Grieshaber Ailis, Hu Zongyi, Jang Eun Sun, Bax Ad, Liang T Jake

Abstract excerpt

Since the emergence of the Omicron variants at the end of 2021, they quickly became the dominant variants globally. The Omicron variants may be more easily transmitted compared to the earlier Wuhan and the other variants. In this study, we aimed to elucidate mechanisms of the altered infectivity associated with the Omicron variants. We systemically evaluated mutations located in the S2 sequence of spike and...

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Identifiers

PMID: 37225764
DOI: 10.1038/s42003-023-04923-x
PMCID: PMC10206564

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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