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Article

Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage and virus transmission.

Cell host & microbe - 9 Mar 2022

Escalera Alba, Gonzalez-Reiche Ana S, Aslam Sadaf, Mena Ignacio, Laporte Manon, Pearl Rebecca L, Fossati Andrea, Rathnasinghe Raveen, Alshammary Hala, van de Guchte Adriana, Farrugia Keith, Qin Yiren, Bouhaddou Mehdi, Kehrer Thomas, Zuliani-Alvarez Lorena, Meekins David A, Balaraman Velmurugan, McDowell Chester, Richt Jürgen A, Bajic Goran, Sordillo Emilia Mia, Dejosez Marion, Zwaka Thomas P, Krogan Nevan J, Simon Viviana, Albrecht Randy A, van Bakel Harm, García-Sastre Adolfo, Aydillo Teresa

Abstract excerpt

SARS-CoV-2 lineages have diverged into highly prevalent variants termed "variants of concern" (VOCs). Here, we characterized emerging SARS-CoV-2 spike polymorphisms in vitro and in vivo to understand their impact on transmissibility and virus pathogenicity and fitness. We demonstrate that the substitution S:655Y, represented in the gamma and omicron VOCs, enhances viral replication and spike protein cleavage. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35150638
DOI: 10.1016/j.chom.2022.01.006
PMCID: PMC8776496

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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