Article

The spike-stabilizing D614G mutation interacts with S1/S2 cleavage site mutations to promote the infectious potential of SARS-CoV-2 variants

2022-05-20

Abstract excerpt

<h4>ABSTRACT</h4> SARS-CoV-2 remained genetically stable during the first three months of the pandemic, before acquiring a D614G spike mutation that rapidly spread worldwide, and then generating successive waves of viral variants with increasingly high transmissibility. We set out to evaluate possible epistatic interactions between the early occurring D614G mutation and the more recently emerged cleavage site mut...

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Literature Corpus work: a68fbed0-3440-5290-b850-c4e9e7b51114
DOI: 10.1101/2022.05.20.492832

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