Article

Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant

2021-08-13

Abstract excerpt

SARS-CoV-2 Delta variant has rapidly replaced the Alpha variant around the world. The mechanism that drives this global replacement has not been defined. Here we report that Delta spike mutation P681R plays a key role in the Alpha-to-Delta variant replacement. In a replication competition assay, Delta SARS-CoV-2 efficiently outcompeted the Alpha variant in human lung epithelial cells and primary human airway tissu...

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Literature Corpus work: 06932cf1-959d-5b98-a6e5-bef15c79a2ae
DOI: 10.1101/2021.08.12.456173

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