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Clone wars: From molecules to cell competition in intestinal stem cell homeostasis and disease

18 Sept 2022

Abstract excerpt

The small intestine is among the fastest self-renewing tissues in adult mammals. This rapid turnover is fueled by the intestinal stem cells residing in the intestinal crypt. Wnt signaling plays a pivotal role in regulating intestinal stem cell renewal and differentiation, and the dysregulation of this pathway leads to cancer formation. Several studies demonstrate that intestinal stem cells follow neutral drift...

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PMID: 36117218
DOI: 10.1038/s12276-022-00854-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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