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Intestinal stem cells heterogeneity and clonal dominance during aging: two faces of the same coin?

Mechanisms of ageing and development - 1 Jul 2020

Sirvinskas Dovydas, Annunziata Francesco, Neri Francesco

Abstract excerpt

Intestinal epithelium undergoes dysfunctions and diseases over time with an exponential increase in the elderly population. Recent studies reported that the intestinal stem cells (ISCs) show a functional decline during aging and a lack of an appropriate cell identity control. Increase of cell-to-cell heterogeneity is a hallmark of aging tissues and organs, however there is little experimental evidence with regard...

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PMID: 32505859
DOI: 10.1016/j.mad.2020.111247

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