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Article

Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells

13 Mar 2018

Abstract excerpt

Many epithelial stem cell populations follow a pattern of stochastic stem cell divisions called 'neutral drift'. It is hypothesised that neutral competition between stem cells protects against the acquisition of deleterious mutations. Here we use a Porcupine inhibitor to reduce Wnt secretion at a dose where intestinal homoeostasis is maintained despite a reduction of Lgr5+ stem cells. Functionally, there is a...

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PMID: 29556067
DOI: 10.1038/s41467-018-03426-2

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