Article
Generalization of cortical MOSTest genome-wide associations within and across samples.
NeuroImage - 1 Nov 2022
Loughnan Robert J, Shadrin Alexey A, Frei Oleksandr, van der Meer Dennis, Zhao Weiqi, Palmer Clare E, Thompson Wesley K, Makowski Carolina, Jernigan Terry L, Andreassen Ole A, Fan Chun Chieh, Dale Anders M
Abstract excerpt
Genome-Wide Association studies have typically been limited to univariate analysis in which a single outcome measure is tested against millions of variants. Recent work demonstrates that a Multivariate Omnibus Statistic Test (MOSTest) is well powered to discover genomic effects distributed across multiple phenotypes. Applied to cortical brain MRI morphology measures, MOSTest has resulted in a drastic improvement...
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