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Article

Understanding the genetic determinants of the brain with MOSTest.

Nature communications - 14 Jul 2020

van der Meer Dennis, Frei Oleksandr, Kaufmann Tobias, Shadrin Alexey A, Devor Anna, Smeland Olav B, Thompson Wesley K, Fan Chun Chieh, Holland Dominic, Westlye Lars T, Andreassen Ole A, Dale Anders M

Abstract excerpt

Regional brain morphology has a complex genetic architecture, consisting of many common polymorphisms with small individual effects. This has proven challenging for genome-wide association studies (GWAS). Due to the distributed nature of genetic signal across brain regions, multivariate analysis of regional measures may enhance discovery of genetic variants. Current multivariate approaches to GWAS are ill-suited...

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PMID: 32665545
DOI: 10.1038/s41467-020-17368-1
PMCID: PMC7360598

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