Article
Vertex-wise multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology.
NeuroImage - 1 Dec 2021
Shadrin Alexey A, Kaufmann Tobias, van der Meer Dennis, Palmer Clare E, Makowski Carolina, Loughnan Robert, Jernigan Terry L, Seibert Tyler M, Hagler Donald J, Smeland Olav B, Motazedi Ehsan, Chu Yunhan, Lin Aihua, Cheng Weiqiu, Hindley Guy, Thompson Wesley K, Fan Chun C, Holland Dominic, Westlye Lars T, Frei Oleksandr, Andreassen Ole A, Dale Anders M
Abstract excerpt
Brain morphology has been shown to be highly heritable, yet only a small portion of the heritability is explained by the genetic variants discovered so far. Here we extended the Multivariate Omnibus Statistical Test (MOSTest) and applied it to genome-wide association studies (GWAS) of vertex-wise structural magnetic resonance imaging (MRI) cortical measures from N=35,657 participants in the UK Biobank. We...
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