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Multivariate genome-wide association study on tissue-sensitive diffusion metrics highlights pathways that shape the human brain

3 May 2022

Abstract excerpt

The molecular determinants of tissue composition of the human brain remain largely unknown. Recent genome-wide association studies (GWAS) on this topic have had limited success due to methodological constraints. Here, we apply advanced whole-brain analyses on multi-shell diffusion imaging data and multivariate GWAS to two large scale imaging genetic datasets (UK Biobank and the Adolescent Brain Cognitive...

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PMID: 35505052
DOI: 10.1038/s41467-022-30110-3

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