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Article

ZEB1 loss increases glioma stem cell tumorigenicity and resistance to chemoradiation

16 Sept 2022

Abstract excerpt

OBJECTIVE: Glioblastoma has been known to be resistant to chemotherapy and radiation, whereas the underlying mechanisms of resistance have not been fully elucidated. The authors studied the role of the transcription factor ZEB1 (zinc finger E-box-binding homeobox 1 protein), which is associated with epithelial-mesenchymal transition (EMT) and is central to the stemness of glioblastoma, to determine its role in...

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PMID: 36115050
DOI: 10.3171/2022.7.jns22259

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