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Characterization of EGFR-reprogrammable temozolomide-resistant cells in a model of glioblastoma

31 Oct 2022

Abstract excerpt

Abstract Temozolomide (TMZ) resistance is a major clinical challenge for glioblastoma (GBM). O 6 -methylguanine-DNA methyltransferase (MGMT) mediated DNA damage repair is a key mechanism for TMZ resistance. However, MGMT-null GBM patients remain resistant to TMZ, and the process for resistance evolution is largely unknown. Here, we developed an acquired TMZ resistant xenograft model using serial implantation of...

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PMID: 36316307
DOI: 10.1038/s41420-022-01230-y

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