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The role of glioma stem cells in chemotherapy resistance and glioblastoma multiforme recurrence

31 May 2015

Abstract excerpt

Glioma stem cells (GSCs) constitute a slow-dividing, small population within a heterogeneous glioblastoma. They are able to self-renew, recapitulate a whole tumor, and differentiate into other specific glioblastoma multiforme (GBM) subpopulations. Therefore, they have been held responsible for malignant relapse after primary standard therapy and the poor prognosis of recurrent GBM. The failure of current...

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PMID: 26027432
DOI: 10.1586/14737175.2015.1051968

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