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Article

ZEB1 regulates glioma stemness through LIF repression

28 Feb 2017

Abstract excerpt

The identification of a stem cell regulatory gene which is aberrantly expressed in glioma and associated with patient survival would increase the understanding of the role of glioma cancer stem cells (GCSCs) in the virulence of gliomas. Interrogating the genomes of over 4000 brain cancers we identified ZEB1 deletion in ~15% (grade II and III) and 50% of glioblastomas. Meta-analysis of ZEB1 copy number status in...

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PMID: 28246407
DOI: 10.1038/s41598-017-00106-x

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