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Characterization of EGFR-reprogrammable temozolomide-resistant cells in a model of glioblastoma

2022-06-16

Abstract excerpt

Temozolomide (TMZ) resistance is a major clinical challenge for glioblastoma (GBM). O 6 -methylguanine-DNA methyltransferase (MGMT) mediated DNA damage repair is a key mechanism for TMZ resistance. However, MGMT-null GBM patients remain resistant to TMZ, and the process for resistance evolution is largely unknown. Here, we developed an acquired TMZ resistant xenograft model using serial implantation of MGMT-null U...

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Literature Corpus work
d6d4182a-6b85-5101-bbbd-ff5bfc118a71
DOI
10.21203/rs.3.rs-1700654/v1
Open publication

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Characterization of EGFR-reprogrammable temozolomide-resistant cells in a model of glioblastomaDOI 10.21203/rs.3.rs-1700654/v1
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