Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cellular heterogeneity contributes to subtype-specific expression of ZEB1 in human glioblastoma.

PloS one - 1 Jan 2017

Euskirchen Philipp, Radke Josefine, Schmidt Marc Sören, Schulze Heuling Eva, Kadikowski Eric, Maricos Meron, Knab Felix, Grittner Ulrike, Zerbe Norman, Czabanka Marcus, Dieterich Christoph, Miletic Hrvoje, Mørk Sverre, Koch Arend, Endres Matthias, Harms Christoph

Abstract excerpt

The transcription factor ZEB1 has gained attention in tumor biology of epithelial cancers because of its function in epithelial-mesenchymal transition, DNA repair, stem cell biology and tumor-induced immunosuppression, but its role in gliomas with respect to invasion and prognostic value is controversial. We characterized ZEB1 expression at single cell level in 266 primary brain tumors and present a comprehensive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Glioblastoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glioma

Share to In Situ Hybridization, Fluorescence

Share to Isocitrate Dehydrogenase

Share to RNA, Neoplasm

Share to Tumor Microenvironment

Share to Zinc Finger E-box-Binding Homeobox 1

Source

Open in PubMed Open full text

Identifiers

PMID: 28945795
DOI: 10.1371/journal.pone.0185376
PMCID: PMC5612763

Genes

ZEB1
EGFR
IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cellular heterogeneity contributes to subtype-specific expression of ZEB1 in human glioblastoma.PMID 28945795Read ↗

ZEB1 expression is increased in IDH1-mutant lower-grade gliomas.Semantic proximity Read ↗

Astrocyte immunosuppressive activity in glioblastoma depends on ZEB1 and is counteracted by CXCL14Semantic proximity Read ↗

ZEB1 regulates glioma stemness through LIF repressionSemantic proximity Read ↗

Mapping the Stemness Landscape of Glioblastoma to Drive Heterogeneity and Drug Resistance: Bridging Pathological Omics with Prognostic OutcomesSemantic proximity Read ↗

Single-cell molecular characterization to partition the human glioblastoma tumor microenvironment (TME) genetic backgroundSemantic proximity Read ↗

Glioblastoma Heterogeneity and Cancer Cell PlasticitySemantic proximity Read ↗

Intrinsic Gene Expression Profiles of Gliomas Are a Better Predictor of Survival than HistologySemantic proximity Read ↗

Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.Semantic proximity Read ↗

Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy targetSemantic proximity Read ↗

Single-Cell Transcriptomics Uncover IBSP as a Mediator of Tumor-Associated Microglia and Macrophages-Driven Glioblastoma ProgressionSemantic proximity Read ↗

Neurodevelopmental hijacking of oligodendrocyte lineage programs drives glioblastoma infiltrationSemantic proximity Read ↗

Improved prognostication of glioblastoma beyond molecular subtyping by transcriptional profiling of the tumor microenvironmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.