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Article

Family History of Prostate and Breast Cancer Integrated with a Polygenic Risk Score Identifies Men at Highest Risk of Dying from Prostate Cancer before Age 75 Years.

Clinical cancer research : an official journal of the American Association for Cancer Research - 14 Nov 2022

Plym Anna, Zhang Yiwen, Stopsack Konrad H, Jee Yon Ho, Wiklund Fredrik, Kibel Adam S, Kraft Peter, Giovannucci Edward, Penney Kathryn L, Mucci Lorelei A

Abstract excerpt

PURPOSE: Family history of prostate cancer is one of the few universally accepted risk factors for prostate cancer. How much an assessment of inherited polygenic risk for prostate cancer adds to lifetime risk stratification beyond family history is unknown. EXPERIMENTAL DESIGN: We followed 10,120 men in the Health Professionals Follow-up Study with existing genotype data for risk of prostate cancer and prostate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36103261
DOI: 10.1158/1078-0432.CCR-22-1723
PMCID: PMC9660541

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