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Article

Adding genetic risk score to family history identifies twice as many high-risk men for prostate cancer: Results from the prostate cancer prevention trial.

The Prostate - 1 Sept 2016

Chen Haitao, Liu Xu, Brendler Charles B, Ankerst Donna P, Leach Robin J, Goodman Phyllis J, Lucia M Scott, Tangen Catherine M, Wang Li, Hsu Fang-Chi, Sun Jielin, Kader A Karim, Isaacs William B, Helfand Brian T, Zheng S Lilly, Thompson Ian M, Platz Elizabeth A, Xu Jianfeng

Abstract excerpt

BACKGROUND: While family history (FH) has been widely used to provide risk information, it captures only a small proportion of subjects with higher genetic susceptibility. Our objective is to assess whether a genetic risk score (GRS) calculated from prostate cancer (PCa) risk-associated single nucleotide polymorphisms (SNPs) can supplement FH for more effective risk stratification for PCa screening...

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PMID: 27197965
DOI: 10.1002/pros.23200
PMCID: PMC5501387

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