Article
Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2015
Amin Al Olama Ali, Benlloch Sara, Antoniou Antonis C, Giles Graham G, Severi Gianluca, Neal David E, Hamdy Freddie C, Donovan Jenny L, Muir Kenneth, Schleutker Johanna, Henderson Brian E, Haiman Christopher A, Schumacher Fredrick R, Pashayan Nora, Pharoah Paul D P, Ostrander Elaine A, Stanford Janet L, Batra Jyotsna, Clements Judith A, Chambers Suzanne K, Weischer Maren, Nordestgaard Børge G, Ingles Sue A, Sorensen Karina D, Orntoft Torben F, Park Jong Y, Cybulski Cezary, Maier Christiane, Doerk Thilo, Dickinson Joanne L, Cannon-Albright Lisa, Brenner Hermann, Rebbeck Timothy R, Zeigler-Johnson Charnita, Habuchi Tomonori, Thibodeau Stephen N, Cooney Kathleen A, Chappuis Pierre O, Hutter Pierre, Kaneva Radka P, Foulkes William D, Zeegers Maurice P, Lu Yong-Jie, Zhang Hong-Wei, Stephenson Robert, Cox Angela, Southey Melissa C, Spurdle Amanda B, FitzGerald Liesel, Leongamornlert Daniel, Saunders Edward, Tymrakiewicz Malgorzata, Guy Michelle, Dadaev Tokhir, Little Sarah J, Govindasami Koveela, Sawyer Emma, Wilkinson Rosemary, Herkommer Kathleen, Hopper John L, Lophatonanon Aritaya, Rinckleb Antje E, Kote-Jarai Zsofia, Eeles Rosalind A, Easton Douglas F
Abstract excerpt
BACKGROUND: Genome-wide association studies have identified multiple genetic variants associated with prostate cancer risk which explain a substantial proportion of familial relative risk. These variants can be used to stratify individuals by their risk of prostate cancer. METHODS: We genotyped 25 prostate cancer susceptibility loci in 40,414 individuals and derived a polygenic risk score (PRS). We estimated...
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