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Article

Inferring the initiation and development of myeloproliferative neoplasms.

Proceedings of the National Academy of Sciences of the United States of America - 13 Sept 2022

Hermange Gurvan, Rakotonirainy Alicia, Bentriou Mahmoud, Tisserand Amandine, El-Khoury Mira, Girodon François, Marzac Christophe, Vainchenker William, Plo Isabelle, Cournède Paul-Henry

Abstract excerpt

The developmental history of blood cancer begins with mutation acquisition and the resulting malignant clone expansion. The two most prevalent driver mutations found in myeloproliferative neoplasms-JAK2V617F and CALRm-occur in hematopoietic stem cells, which are highly complex to observe in vivo. To circumvent this difficulty, we propose a method relying on mathematical modeling and statistical inference to...

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Identifiers

PMID: 36083966
DOI: 10.1073/pnas.2120374119
PMCID: PMC9478641

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